Berberine has become one of the most talked-about ingredients in metabolic health. MOTUS starts with an advanced form of berberine — then builds a more complete formula around it.
Berberine is one of the most studied plant compounds for metabolic health. It is found in plants such as barberry and goldenseal, and it helps support healthy glucose metabolism. The challenge is not whether berberine is useful. It is how little of it the body actually takes in.
Conventional route
Generic Amber Bottle
Standard botanical extract salt
High Daily Volume
1500 mg per day required
Multiple Daily Doses
Split into 2–3 separate doses taken with meals
Absorption Bottleneck
Low absorption well documented: ≤5% reaches systemic circulation due to poor solubility and active gut wall efflux.
Proven botanical foundation, but requires disciplined multi-dose scheduling.
Phytosome route (MOTUS)
MOTUS Single Daily Serving
Bound to dietary phospholipids for bio-transport
Phospholipid Carrier Complex
Berberine is bound to phospholipids (the same fats composing human cell membranes)
Facilitated Intestinal Permeation
Helps the compound dissolve and cross the intestinal barrier more readily
Single Morning Convenience
Delivers 500 mg Berbevis® in one morning serving without needing to stack high multi-gram doses across the day.
Developed by Indena
Study data
Biomimetic lipid complexClinical trial parameters
Human pharmacokinetics
Berbevis® is a berberine phytosome developed by Indena. Berberine is bound to phospholipids, the same fats that make up cell membranes, which helps it dissolve and cross the gut wall more easily.
Its absorption was tested in a randomized, double-blind, crossover study at Araba University Hospital in Spain (Petrangolini et al., 2021). Twelve healthy adults aged 18 to 50 took either 500 mg of standard berberine or berberine phytosome on separate occasions, under fasting conditions, and researchers tracked berberine in their blood over the following hours.
Berberine phytosome produced significantly higher blood levels of berberine than standard berberine, and no side effects were observed.
The practical difference: Motus delivers 500 mg of Berbevis® in one morning serving, so there is no need to spread large doses across the day.
A side-by-side look at the most common ways to take berberine.
| Parameter | motus | Standard berberine HCl Traditional botanical salt | Berberine blends Multi-herb mixtures |
|---|---|---|---|
| Berberine form | Berbevis® phytosome | Berberine hydrochloride | Usually berberine HCl |
| Human absorption data for the form | Yes | Low absorption well documented | Depends on form |
| Berberine per day | 500 mg Berbevis® | Typically 1,500 mg | Varies |
| Doses per day | 1 (4 capsules, morning) | Usually 2-3 | Varies |
| Supporting ingredients | Siliphos®, alpha-lipoic acid, nicotinamide, taurine | None | Often cinnamon or chromium |
| Human study of the finished formula | Yes, 26 weeks, 100 adults | Rarely | Rarely |
| Stimulants | None | Usually none | Varies |
| Certification | NSF certified, GMP | Varies | Varies |
A research-driven, five-ingredient metabolic-support formula built around Berbevis® berberine phytosome.
Free shipping on 3 months and up • HSA/FSA eligible • Ships in 1 business day
A standard berberine supplement stops at berberine. Motus was developed through nearly a decade of research with Duke University to pair it with four ingredients that support metabolism from different angles. See the full formula.
| Ingredient | Per serving | Why it’s in Motus |
|---|---|---|
|
Berbevis® (berberine phytosome)Phospholipid Phytosome Carrier
|
500 mg | A better-absorbed form of berberine that helps support healthy glucose metabolism. |
|
Siliphos® (milk thistle phytosome)Phospholipid Phytosome Carrier
|
550 mg | Silybin from milk thistle, bound to phospholipids for absorption, to help support normal liver function. |
|
Alpha-lipoic acid
|
300 mg | An antioxidant that helps support healthy glucose metabolism and cellular energy. |
|
Nicotinamide (vitamin B3)
|
500 mg NE | Helps support normal energy metabolism through NAD+ production. |
|
Taurine
|
400 mg | An amino acid that helps support muscle and cellular energy during weight management. |
Each ingredient was chosen to cover a different part of metabolism. Berbevis® and alpha-lipoic acid both help support healthy glucose metabolism. Nicotinamide helps support energy production at the cellular level. Taurine helps support muscle during weight management, and Siliphos® helps support the liver, which does much of the work of processing fats.
Glycemic balance
01Berbevis® (500 mg) + Alpha-Lipoic Acid (300 mg)
Berbevis® and alpha-lipoic acid both help support healthy glucose uptake and insulin signaling pathways.
NAD+ support
02Nicotinamide (500 mg NE)
Helps support normal cellular energy production and mitochondrial function through NAD+ synthesis.
Lean mass
03Taurine (400 mg)
An essential amino acid that helps support muscle integrity and cellular hydration during weight management.
Hepatic function
04Siliphos® (550 mg)
Silybin bound to phospholipids supports the liver, which does much of the biological work of processing circulating fats.
An objective look at delivery forms, ingredient synergy, and clinical methodology.
100
Adults enrolled
26weeks
Study duration
10.4%
Average total body-weight loss among participants
completing the 24-week extension
87% of the reported weight loss came from fat rather than lean mass.
Scientific provenance
Motus was developed through nearly ten years of research with Duke University. Researchers evaluated around a million compounds before selecting the five natural ingredients in the formula.
Visit Our Research to see the full body of work.
~10 yrs
Collaborative metabolic research with Duke
University scientists.
~1M
Screening botanical and cellular candidates
for synergy and tolerability.
5
Berbevis®, Siliphos®, ALA, Nicotinamide, and
Taurine combined.
MOTUS
Tested in a 26-week clinical trial of 100 human adults.
Results build gradually. Most customers report noticing changes over 60 to 90 days of consistent daily use, which is why Motus is designed as a daily routine rather than a quick fix.
Optimal Observation Window
60–90 DAYS
Metabolic cellular adaptations occur progressively. Unlike stimulant-driven products that force temporary spikes, phytosome delivery supports stable baseline glucose and liver metabolism over time.
Days 1–30
Establishing consistent morning routine and phospholipid absorption.
Days 30–60
Steady support for glucose management and cellular energy.
Days 60–90+
Noticeable body composition improvements and sustained metabolic health.
Recommended protocol: 4 capsules once daily in the morning with food
There is no single right answer for everyone. Here is an honest way to think about it.
Category 01
May suit you if you want a single, well-studied ingredient at a lower price and are comfortable taking it two or three times a day.
Category 02
May suit you if you want better absorption than standard berberine but only need berberine itself.
Category 03
Suits you if you want a better-absorbed form of berberine plus four supporting ingredients in one morning serving, backed by a human study of the complete formula. Most people who take Motus are women around 50 looking for metabolic support that fits into everyday life.
Berbevis® is berberine bound to phospholipids (a phytosome), which helps the body absorb it. In a human pharmacokinetic study, berberine phytosome produced significantly higher blood levels of berberine than standard berberine.
Berberine phytosome is absorbed better than berberine HCl, according to human pharmacokinetic research. Berberine HCl is the most widely studied form, but studies typically use 1,000-1,500 mg a day split into two or three doses.
Each daily serving of Motus (4 capsules) contains 500 mg of Berbevis®, which provides about 140 mg of berberine in a better-absorbed phytosome form, alongside Siliphos®, alpha-lipoic acid, nicotinamide, and taurine.
Take 4 capsules once a day, in the morning, with food. One bottle holds 120 capsules, a full 30-day supply.
Motus was studied as a complete formula in a 26-week human study, which most berberine supplements have not been. Because it combines five ingredients, the results reflect the formula as a whole, and individual results vary.
No. Motus already contains berberine, so taking it with another berberine supplement is not recommended. Speak with a healthcare provider before combining supplements.
Speak with a healthcare provider first. Berberine can interact with some medicines, including those that affect blood sugar. If you are pregnant or nursing, consult a healthcare professional before use.
No. Motus is stimulant-free, with no caffeine, so there are no jitters or crashes.
Yes, most people can. Our guide on berberine and coffee covers timing and what to watch for.
Berbevis® plus four supporting ingredients, in one morning serving. Stimulant-free, NSF certified, and studied as a complete formula.
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